---
title: "ParCC Tutorial Index"
output: rmarkdown::html_vignette
vignette: >
  %\VignetteIndexEntry{ParCC Tutorial Index}
  %\VignetteEngine{knitr::rmarkdown}
  %\VignetteEncoding{UTF-8}
---

```{r, include = FALSE}
knitr::opts_chunk$set(collapse = TRUE, comment = "#>")
```

## ParCC Vignette Library

**ParCC (Parameter Converter & Calculator)** provides a comprehensive set of tutorials organized by topic. Each vignette includes realistic clinical scenarios, worked examples with R code, and references to the underlying methodology.

### Getting Started

- **`vignette("getting-started")`**  --  Installation, launching the app, and the Lab Notebook workflow

### Core Conversions

- **`vignette("core-conversions")`**  --  Rate to Probability, Odds to Probability, and Time Rescaling with real-world examples from the RE-LY trial and UKPDS Risk Engine

### Hazard Ratio Conversion (NEW in v1.3.0)

- **`vignette("hr-probability-converter")`**  --  Converting control group probabilities to intervention probabilities using Hazard Ratios. Includes worked examples from the PLATO trial (Ticagrelor vs Aspirin) and oncology models.

### Survival Extrapolation

- **`vignette("survival-extrapolation")`**  --  Fitting Exponential and Weibull survival curves from published Kaplan-Meier data when IPD is unavailable

### Background Mortality

- **`vignette("background-mortality")`**  --  SMR adjustment, DEALE, Gompertz parameterization, and linear interpolation for adjusting census life tables to disease-specific cohorts

### Probabilistic Sensitivity Analysis

- **`vignette("psa-distributions")`**  --  Fitting Beta (utilities), Gamma (costs), and LogNormal (HRs) distributions using the Method of Moments. Includes the Rule of 4 approximation.

### Economic Evaluation

- **`vignette("economic-evaluation")`**  --  ICER calculation, Net Monetary Benefit, and Value-Based Pricing (Headroom Analysis) with Indian HTA context

### Batch Processing

- **`vignette("batch-workflow")`**  --  Uploading CSV files for bulk conversion, including the new HR-based batch conversion

## Key References

- **Sonnenberg FA, Beck JR.** Markov models in medical decision making. *Med Decis Making*. 1993;13(4):322-338.
- **Briggs A, Claxton K, Sculpher M.** *Decision Modelling for Health Economic Evaluation*. Oxford University Press; 2006.
- **Collett D.** *Modelling Survival Data in Medical Research*. 3rd ed. Chapman and Hall/CRC; 2015.
- **Drummond MF, et al.** *Methods for the Economic Evaluation of Health Care Programmes*. 4th ed. Oxford University Press; 2015.
- **Cosh E, et al.** The value of 'innovation headroom'. *Value in Health*. 2007;10(4):312-315.
- **NICE DSU.** Technical Support Document 14: Survival analysis for economic evaluations. 2013.
