twoCoprimary: Sample Size and Power Calculation for Two Co-Primary Endpoints

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

Version:	1.0.0
Depends:	R (≥ 3.5.0)
Imports:	mvtnorm, pbivnorm, fpCompare, stats
Suggests:	dplyr, knitr, rmarkdown, testthat (≥ 3.0.0), tibble, tidyr, readr
Published:	2025-11-21
DOI:	10.32614/CRAN.package.twoCoprimary (may not be active yet)
Author:	Gosuke Homma [aut, cre]
Maintainer:	Gosuke Homma <my.name.is.gosuke at gmail.com>
BugReports:	https://github.com/gosukehommaEX/twoCoprimary/issues
License:	MIT + file LICENSE
URL:	https://gosukehommaex.github.io/twoCoprimary/, https://github.com/gosukehommaEX/twoCoprimary
NeedsCompilation:	no
Language:	en-US
Materials:	README, NEWS
CRAN checks:	twoCoprimary results

Documentation:

Reference manual:	twoCoprimary.html , twoCoprimary.pdf
Vignettes:	Mixed Continuous and Binary Co-Primary Endpoints (source, R code) Mixed Count and Continuous Co-Primary Endpoints (source, R code) Overview of Two Co-Primary Endpoints Analysis (source, R code) Two Binary Co-Primary Endpoints (Asymptotic Methods) (source, R code) Two Binary Co-Primary Endpoints (Exact Methods) (source, R code) Two Continuous Co-Primary Endpoints (source, R code)

Downloads:

Package source:	twoCoprimary_1.0.0.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): twoCoprimary_1.0.0.tgz, r-oldrel (arm64): twoCoprimary_1.0.0.tgz, r-release (x86_64): twoCoprimary_1.0.0.tgz, r-oldrel (x86_64): twoCoprimary_1.0.0.tgz

Linking:

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