[BioC] asymmetry in up and down regulation

Ben Bolstad bolstad at stat.berkeley.edu
Mon Aug 11 23:09:32 MEST 2003

I don't think that this is really a bias. There are probesets that have
been observed to perform much like the "official" spikeins for various
reasons. See


for details. These probesets would be giving the asymmetry out in the
extremes of the plot you referred to.


On Mon, 2003-08-11 at 14:47, Chris Paulse wrote:
> Figure 5 in the recent Nucleic Acids Research 2003, Vol. 31, No. 4 e15
> (http://nar.oupjournals.org/cgi/content/full/31/4/e15/GNG015F5) shows an 
> interesting asymmetry in the distribution of fold changes for non-spiked in 
> genes.  Can anyone comment on the reason for this?  Here, dChip has the 
> least amount of bias.
> Thanks,
> Chris
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Ben Bolstad <bolstad at stat.berkeley.edu>

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