[BioC] p-value adjustment when two or more genes are compared at same time

Jason Liao jg_liao at yahoo.com
Tue Aug 12 10:01:13 MEST 2003

Hello, everyone! I have used bioconductor for analyzing some microarray
data. Thanks to you all for the excellent work.

I have a p-value adjustment question. The standard approach seems to
compare the gene expression levels between cancer and normal tissues
one gene at a time. The p-values can then be adjusted for multiple
comparisons using the package multtest by Yongchao Ge and Sandrine
Dudoit. What I am doing is to fit a logistic regression, with the
cancer or normal as the binary outcome and several selected genes as
the predictors. My question is how to adjust the p-value from the
logitsic regression? Any help will be highly appreciated.


Jason G. Liao, Ph.D.
Division of Biometrics
University of Medicine and Dentistry of New Jersey
335 George Street, Suite 2200
New Brunswick, NJ 08903-2688
phone (732) 235-8611, fax (732) 235-9777

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