[BioC] splitting clusters and cluster significance

Robert Gentleman rgentlem at jimmy.harvard.edu
Wed Sep 24 15:40:04 MEST 2003

On Wed, Sep 24, 2003 at 01:20:48PM -0400, Subramanian Karthikeyan wrote:
> Hi All:
> I am clustering ~500 genes using hclust of R.  Visualizing cluster
> membership in the dendrogram becomes impossible with so many genes in each
> cluster. with all the labels overlapping..Is there a way of printing the
> dendrogram on multiple pages so that I can clearly see what is in each
> cluster? Or is there a way of splitting the tree so that I see what is in
> each cluster....?

  cutree  will cut the tree
> Again, how would I test the significance of clustering...i mean a measure
> of telling how tight my clusters are, and how separated they are from each
> other.

  that's harder - there are books, chapters in books and many papers
  on the subject - Gordon's book, Classification (which is mainly
  about clustering, in the sense you are using the word) has some good
  explanations of different methods; but there are, as I said, many

> Thanks in advance.
> Karthi.
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| Robert Gentleman                 phone : (617) 632-5250                   |
| Associate Professor              fax:   (617)  632-2444                   |
| Department of Biostatistics      office: M1B20                            |
| Harvard School of Public Health  email: rgentlem at jimmy.harvard.edu        |

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