[BioC] detection vs. detection of change

[A.J. Rossini]

"John Welsh" <jwelsh at skcc.org> writes:

> I'd like to know whether an intensity signal in a microarray is large
> enough that, if its gene were downregulated, it would be
> detected. That is, what proportion of the probes can be "detected" in
> the target? I'm trying to explore this by dividing random subsets of
> the experimental (i.e. "R") intensities by a small factor, and asking
> what proportion of these simulated changes limma detects. Does this
> sound reasonable? Is there a better way?

Are you talking about a single chip or a multiple chip experiment?

And the technology used is relevant as well (single-channel or
dual-channel, and platform)?
 
best,
-tony

-- 
Anthony Rossini			    Research Associate Professor
rossini at u.washington.edu            http://www.analytics.washington.edu/ 
Biomedical and Health Informatics   University of Washington
Biostatistics, SCHARP/HVTN          Fred Hutchinson Cancer Research Center
UW (Tu/Th/F): 206-616-7630 FAX=206-543-3461 | Voicemail is unreliable
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