[BioC] detection vs. detection of change

A.J. Rossini rossini at blindglobe.net
Fri Jul 16 18:33:56 CEST 2004

"John Welsh" <jwelsh at skcc.org> writes:

> I'd like to know whether an intensity signal in a microarray is large
> enough that, if its gene were downregulated, it would be
> detected. That is, what proportion of the probes can be "detected" in
> the target? I'm trying to explore this by dividing random subsets of
> the experimental (i.e. "R") intensities by a small factor, and asking
> what proportion of these simulated changes limma detects. Does this
> sound reasonable? Is there a better way?

Are you talking about a single chip or a multiple chip experiment?

And the technology used is relevant as well (single-channel or
dual-channel, and platform)?

Anthony Rossini			    Research Associate Professor
rossini at u.washington.edu            http://www.analytics.washington.edu/ 
Biomedical and Health Informatics   University of Washington
Biostatistics, SCHARP/HVTN          Fred Hutchinson Cancer Research Center
UW (Tu/Th/F): 206-616-7630 FAX=206-543-3461 | Voicemail is unreliable
FHCRC  (M/W): 206-667-7025 FAX=206-667-4812 | use Email

CONFIDENTIALITY NOTICE: This e-mail message and any attachme...{{dropped}}

More information about the Bioconductor mailing list