[BioC] Multiple testing correction on 2-Way ANOVA

[Eric]

Hi,

I apologize for this being off-topic- it's really a statistical question 
but I'd be interested in the community's input. If I run a 'per gene' 2-way 
ANOVA on single channel microarray data (i.e., each gene is tested 
separately by 2-Way ANOVA), should I run multiple testing correction for 
each factor and interaction separately? Alternatively, should I use an 
overall (omnibus) F-test, correct that for multiple testing, and treat the 
main effects and interaction results as post-hoc to the overall test?

Thanks,
-E

Eric Blalock, PhD
Dept Pharmacology, UKMC
859 323-8033

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