[BioC] RMA and quantile normalisation

Mark Reimers reimersm at mail.nih.gov
Fri Mar 5 20:22:41 MET 2004


Hello Arne,
Several publications recently have shown that the distribution of gene
abundances seems to follow a power law (one such is referenced at
www.the-scientist.com. This should turn into an exponential density on the
log scale we often use. The 'hump' we see in signal intensities from
microarray experiments probably reflects variable levels of non-specific
hybridization to each probe. If we could estimate this, we would be further
along in estimating fold changes.

regards
Mark



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