[BioC] dupcor.series

[Jason Skelton]

Hi Gordon

I've received and error message with limma that I haven't come across before
but I only receive it with data that has been normalised between arrays:

cor <- dupcor.series(NWAresults$M, design, ndups=2, spacing=840)
works fine but if I try:


nbaResults <- normalizeBetweenArrays(NWAresults)
then:
cor <- dupcor.series(nbaResults$M, design, ndups=2, spacing=840)

It returns:

*Error in chol(dinfo) : the leading minor of order 2 is not positive 
definite.*

there are only two slides in this particular experiment could this be 
part of the problem ?


Thanks

Jason

-- 
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Jason Skelton
Pathogen Microarrays
Wellcome Trust Sanger Institute
Hinxton
Cambridge
CB10 1SA

Tel +44(0)1223 834244 Ext 7123
Fax +44(0)1223 494919
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