[BioC] Gene selection: association with linear response and
correction for multi test
david neil hayes
davidneilhayes at hotmail.com
Tue Apr 5 19:57:56 CEST 2005
I am interested in selecting genes associated with a linear outcome (drug
dose) and including adjustments for multiple testing/false discovery. As an
example, the Excel version of SAM, for example, has an implementation where
the delta statistic is based on the linear regression coefficient.
Am I correct, this response type is not supported in either the development
or current release of siggenes?
I re-reviewed siggenes and reviewed the limma package (with which I am less
familiar), as well as some of the on-line Bioconductor tutorials, and it was
not clear to me that there was an application that I could select as a
"standard" method (or at least a method with published references) of
selecting genes associated with a linear response.
This strikes me as a question similar to one that has been asked many times
before, but on review of the mail archives, I couldn't find an answer. I am
sure I am missing something simple. Any suggestions?
UNC Chapel Hill
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