[BioC] genes variances

Naomi Altman naomi at stat.psu.edu
Wed Apr 27 05:06:27 CEST 2005

There is an interesting paper by Churchill (probably at his website at 

At 10:44 AM 4/22/2005, Robert Gentleman wrote:
>Hmm, google will do most of that work for you, Wolfgang Huber has done
>a lot of work on this (see the package vsn, which contains code for
>carrying out such an analysis).
>On Apr 22, 2005, at 5:12 AM, E Motakis, Mathematics wrote:
>>Dear all,
>>Recently, I have been working on variance stabilization techniques for
>>cDNA microarrays. I have been studying the papers:
>>I. Rocke and Durbin, (2001), `A model for measurement error for gene
>>expression arrays', J. Comput. Biol, 8, 557--569 and
>>II. Durbin, Hardin, Hawkins, and Rocke, (2002), `A
>>variance-stabilizing transformation for gene-expression microarray
>>data', Bioinformatics, 18, S105-S110.
>>Their variance stabilization seems to work well for most of the genes
>>I replicate (and for my data). I wonder if someone is aware of other
>>related papers to that subject (not only by those authors). Is there
>>any other technique for variance stabilization available in the
>>microarrays literature?
>>Thank you in advance.
>>Makis Motakis
>>E Motakis, Mathematics
>>E.Motakis at bristol.ac.uk
>>Bioconductor mailing list
>>Bioconductor at stat.math.ethz.ch
>| Robert Gentleman              phone: (206) 667-7700
>          |
>| Head, Program in Computational Biology   fax:  (206) 667-1319   |
>| Division of Public Health Sciences       office: M2-B865
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>| Fred Hutchinson Cancer Research Center
>          |
>| email: rgentlem at fhcrc.org
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Naomi S. Altman                                814-865-3791 (voice)
Associate Professor
Bioinformatics Consulting Center
Dept. of Statistics                              814-863-7114 (fax)
Penn State University                         814-865-1348 (Statistics)
University Park, PA 16802-2111

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