[BioC] backgroundCorrect(method="normexp") problems

Gordon Smyth smyth at wehi.edu.au
Fri Apr 29 12:19:02 CEST 2005

You'll see this question asked a few times in the mailing list archives. 
Try upgrading your version of the limma package.


>Date: Thu, 28 Apr 2005 16:44:41 -0400
>From: "Palmer, Lance" <palmer at cshl.edu>
>Subject: [BioC] backgroundCorrect(method="normexp")  problems
>To: <bioconductor at stat.math.ethz.ch>
>I am just starting to do microarray analysis.  I have been trying to 
>normalize 4 chips (two dye-swap experiments done in biological replicates)
>After doing backgroundCorrect(method="normexp") , one of the arrays has 
>all of its $G values at NaN.
>This does not happen when any other method is used.
>Can someone tell me why this is, and if this can be fixed?
>Lance Palmer

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