[BioC] Significant dye bias using limma
mark.pinese at student.unsw.edu.au
Thu Jul 21 03:07:46 CEST 2005
Will such a significant bias affect the validity of my treatment effect
results? In other words, can I just appreciate that dye bias is
rampant, then ignore it and confidently extract meaningful statistics
from my treatment vs control coefficient?
Gordon K Smyth wrote:
>The fact that the dye effect is often highly significant is the reason that it is recommended to
>include it in the model.
>>Is such a strong result plausible, or due to me incorrectly analysing the data?
>> If so, what major pitfalls could I have blundered into? What sort of
>>diagnostics can I try to test how reliable the model results are?
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