[BioC] paired t test for siblings?

[Naomi Altman]

I would use Limma, with sib pairs as a block.  This has all the 
advantages of a paired t-test with better power.


At 12:53 PM 11/7/2005, Li,Qinghong,ST.LOUIS,Molecular Biology wrote:
>Hi BioC,
>
>I have a data set from an experiemnt that has a control and a 
>treatment group for a total of 8 dogs. Each group has 4 bioloigical 
>replicates (4 dogs). Animals are in pairs in terms of siblings. Is 
>paired test appropriate in this case?
>
>Due to low replicate number (4), is traditional t test appropriate? 
>If not, what would be other options in BioC packages besides SAM?
>
>Thanks in advance!
>Johnny
>
>
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Naomi S. Altman                                814-865-3791 (voice)
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