[BioC] repeated measures in limma?

[Naomi Altman]

The subjects are blocks.

Have a look at the duplicateCorrelation command and the example for 
randomized block designs.

--Naomi

At 06:42 AM 11/10/2005, rob foxall (IFR) wrote:
>Hi,
>         My problem is as follows: I have a bunch of subjects with a
>medical condition, and a bunch of normals, and I am looking for
>differences between the two groups. However, I have several arrays per
>subject (biological replicates), and so would like to include subject
>variability into the model. If this was a usual single-response problem,
>I might use the package "nlme" from R, something like
>
>fit <- lme(fixed=response ~ condition, data=mydata, random= ~1 |
>Subject)
>
>Is there something analogous to this in limma?
>
>Cheers,
>         Rob.
>
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Naomi S. Altman                                814-865-3791 (voice)
Associate Professor
Dept. of Statistics                              814-863-7114 (fax)
Penn State University                         814-865-1348 (Statistics)
University Park, PA 16802-2111