[BioC] ANCOVA in limma

Naomi Altman naomi at stat.psu.edu
Wed Oct 19 20:26:42 CEST 2005

We would like to adjust our ANOVA-type analysis by using the 
covariate "age".  Because limma is based on contrast, rather than 
"type III SS", it seems to me that the only way to proceed with an 
ANCOVA-type analysis is to orthogonalize the design matrix against 
the covariate.  Is there a more straight-forward method?

Naomi S. Altman                                814-865-3791 (voice)
Associate Professor
Dept. of Statistics                              814-863-7114 (fax)
Penn State University                         814-865-1348 (Statistics)
University Park, PA 16802-2111

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