[BioC] gene expression baseline adjustment for pre/post treatment
junxu8 at yahoo.com
Sat Sep 3 02:34:53 CEST 2005
We have an experiment in which 30 subjects were divided into two groups (15
treatment and 15 control). Gene expressions were measured before and after
treatment for both groups. I am wondering what is the best way to do baseline
adjustment? Several ways of analysis are in consideration.
1. Post treatment gene expression only.
2. Difference in Post/pre treatment
3. ANCOVA using baseline gene expression as covariate for each gene.
Any suggestion? If using ANCOVA, is it required to use the parallel line model?
More information about the Bioconductor