[BioC] adjustment for dependent hypotheses when pairwise testing
naomi at stat.psu.edu
Fri Jan 13 22:57:28 CET 2006
I do not think you will be able to use these methods with such a
small number of genes. A large number of genes are required to estimate pi0.
At 07:52 AM 1/13/2006, pmt1rew at leeds.ac.uk wrote:
>I data for 13 genes with the samples from 4 different tissue
>types. Would like
>to compare the normal means of the different tissue types using pairwise
>testing with an adjustment for fdr.
>Having considered the Benjamini and Yekutieli reference on the p.adjust help
>page I am unsure as to whether my dependency structure satisfies the criteria
>to just use the regular "BH" adjustment or if the "BY" adjustment would be
>Any suggestions for me please?
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>Bioconductor at stat.math.ethz.ch
Naomi S. Altman 814-865-3791 (voice)
Dept. of Statistics 814-863-7114 (fax)
Penn State University 814-865-1348 (Statistics)
University Park, PA 16802-2111
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