[BioC] Fitting mixture of beta-distributions

[Kevin R. Coombes]

Hi,

An equivalent method (BUM) was also described by Pounds and Morris in 
Bioinformatics in early 2003.  BUM is implemented in OOMPA, which is 
available at http://bioinformatics.mdanderson.org/software.html, and if 
I ever feel like I have time to maintain it through the steady pace of 
new BioConductor releases, then I'll submit OOMPA.

For more general mixtures of betas, you might also look at

Ji Y, Wu C, Liu P, Wang J, Coombes KR. Applications of beta-mixture 
models in bioinformatics. Bioinformatics. 2005 May 1;21(9):2118-22.

  -- Kevin

Claus Mayer wrote:
> Dear all!
> 
> I assume that some of you are aware of a paper by Allison et al from 
> 2002 where they discuss fitting a mixture of beta-distributions (one of 
> them being the uniform) to the distribution of p-values from a 
> microarray experiment.
> 
> Has this been implemented into Bioconductor somewhere or is one of you 
> aware of other R libraries that could help with fitting mixture of betas?
> 
> Thanks,
> 
> Claus