[BioC] Finding peaks on tiling arrays/ moving average?

[J.delasHeras at ed.ac.uk]

Dear all,

I am looking at some tiling arrays (actually, not quite tiling... they  
have a 50bp oligo every 100bp or so) for a given chromosome.

They have been hybridised with the product of ChIP using antibodies  
against several chromatin proteins.

I am interested in some particular genes, and as I know their location  
I can easily find them and see what the patter is around them.
But I am also interested in just finding where these proteins bind  
along the chromosome.

Does anybody know of a procedure (or even a package) that would be  
useful for this purpose? I imagine that using moving averages (or  
medians) with a window teh same length as my average ChIP fragment  
would be a way to start, but then I have to come up with a way to give  
probes scores etc... and I feel that I'd just be reinventing the wheel.

Any ideas/pointers would be very much appreciated! Thanks!

Jose


-- 
Dr. Jose I. de las Heras                      Email: J.delasHeras at ed.ac.uk
The Wellcome Trust Centre for Cell Biology    Phone: +44 (0)131 6513374
Institute for Cell & Molecular Biology        Fax:   +44 (0)131 6507360
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University of Edinburgh
Edinburgh EH9 3JR
UK