[BioC] Question on background correction using RMA

[James W. MacDonald]

Hi Malick,

Malick.PAYE at eu.biomerieux.com wrote:
> hello,
> 
> I work for an invitro diagnostic company (www.biomerieux.com) and we are 
> interested in microarray data analysis (we are working with affymetrix 
> chips).
> 
> I would like to know if Mismatch are used in RMA background correction 
> method for the estimation of some parameters of the underlying model.

The quick answer is no. You might want to read some of the papers 
describing this method which will clarify the background estimation.

See here for a selection:

http://www.biostat.jhsph.edu/~ririzarr/papers/index.html

Best,

Jim


> 
> Thanks in advance.
> 
> M.P
> 
> Malick Paye | bioMérieux | Biomathematician
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