[BioC] Question on background correction using RMA

James W. MacDonald jmacdon at med.umich.edu
Wed Jun 27 16:02:18 CEST 2007

Hi Malick,

Malick.PAYE at eu.biomerieux.com wrote:
> hello,
> I work for an invitro diagnostic company (www.biomerieux.com) and we are 
> interested in microarray data analysis (we are working with affymetrix 
> chips).
> I would like to know if Mismatch are used in RMA background correction 
> method for the estimation of some parameters of the underlying model.

The quick answer is no. You might want to read some of the papers 
describing this method which will clarify the background estimation.

See here for a selection:




> Thanks in advance.
> M.P
> Malick Paye | bioMérieux | Biomathematician
> Phone: (+33)4 78 87 70 97 | Fax: (+33)4 78 87 53 40
> [Centre Cristophe Mérieux, 5 Rue des Berges, 38004 Cedex 01  Grenoble, 
> France]
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