[BioC] quantile normalization of one dataset to another

Daniel Brewer daniel.brewer at icr.ac.uk
Tue May 22 16:17:41 CEST 2007


I have two different datasets which are both originally from the
Affymetrix platform but now I only have the expression matrix.  Both
datasets have an overall different distribution of expression.  What I
would like to do is quantile normalisation on each of the experiments in
one dataset to the quantile curve of the other dataset i.e. I want to
leave the second dataset untouched, but normalise the first to it.  ANy
ideas how to do this?  I looked at normalize.quantiles but it does not
appear to do what I want.



Daniel Brewer, Ph.D.
Institute of Cancer Research
Molecular Carcinogenesis
Email: daniel.brewer at icr.ac.uk

The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP.

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