[BioC] GOstats - defining the gene universe

[Rachael McBride]

Hi,

I have a quick question that I can't seem to find an answer to by 
searching the BioC lists. I want to use GOstats on a gene list. I've 
read the vignette and understand that defining the gene universe is an 
important step. The vignette outlines various non-specific filtering 
steps that can be done on an expression set in order to define the gene 
universe. My question is are the non-specific filtering steps done on a 
normalized or un-normalized expression set.

Thanks,
Rachael