[BioC] Bimodal Distrinbution
sdavis2 at mail.nih.gov
Tue Dec 9 20:26:48 CET 2008
Sorry, Francesco. You'll probably need to provide some more detail.
We don't even know whether you have mass-spec data, protein arrays,
IHC, or some other assay. Perhaps there is a package in Bioconductor
that can help, but you'll have to give folks a bit more to work with
to figure that out.
On Tue, Dec 9, 2008 at 2:12 PM, Francesco Mancuso
<francesco.mancuso at ifom-ieo-campus.it> wrote:
> Hi Sean!
> Everything...but principally what you said.
> I have to normalize data, then to look for "differential express"
> protein and calculate a p-value of how much the outliers differs from
> Finally I have to map a set of proteins into the distribution to
> understand if they are over-expressed in a mutant proteome.
> Sean Davis wrote:
>> On Tue, Dec 9, 2008 at 1:19 PM, Francesco Mancuso
>> <francesco.mancuso at ifom-ieo-campus.it> wrote:
>>> Hi all!
>>> I'm a little newbie with R...
>>> I'm working with quantitative proteomics data that have a bimodal
>>> For you what is the best function to work with this type of data?
>> Hi, Francesco.
>> What do you want to do with the data? Are you looking for
>> differential expression? Trying to normalize data?
> *Francesco Mattia Mancuso*
> /Proteomics and Functional Genomics Group/
> /Mass Spectrometry Unit/
> European Institute of Oncology
> Via Adamello 16 - 20139 Milano
> [Ph] +39-02-94375102
> [email] francesco.mancuso at ifom-ieo-campus.it
> <mailto:francesco.mancuso at ifom-ieo-campus.it>
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