[BioC] Clustering question
srini_iyyer_bio at yahoo.com
Tue Feb 5 21:47:58 CET 2008
apologies this question is not directed to any
bioconductor package, but a simple bioinformatics
I have gene expression data cDNA array.
The design is:
total 6 samples (3 treated, 3 untreated) with time
Time 1: Sample1-treated/Sample1-untreated
Time 2: Sample 2- treated / Sample 2-untreated
Time 3 : Sample 3 - treated / Sample - 3 untreated
Now I have fold-changes for Time1, Time2 and Time3.
Is it possible to do a clustering here by creating a
Genes Time-1 Time-2 Time-3
Is doing a simple Hierarchical clustering between all
time points a meaningful approach because the fold
changes are specific to a particular time point.
(reference samples is not universal but specific to a
Could anyone kindly educate me here. Apologies again
if this question is a misfit.
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