[BioC] RMA bgcorrection question
bmb at bmbolstad.com
Wed Feb 6 05:01:44 CET 2008
No you don't look like an idiot and you are not doing anything wrong.
What you are seeing is quite common from the standard implementation.
A previous thread discussing this issue
On Tue, 2008-02-05 at 19:06 -0800, Siobhan A. Braybrook wrote:
> Dear all,
> At the risk of looking like an idiot:
> is rma background correction supposed to make log-intensity histograms bimodal?
> I noticed this in my own data, then checked it using the Dilution set too
> (see below).
> This seems weird to me........am I doing something wrong?
> dil.rma<- bg.correct(Dilution, method="rma")
> S. A. Braybrook
> Graduate Student, Harada Lab
> Section of Plant Biology
> University of California, Davis
> Davis, CA 95616
> Ph 530.752.6980
> The time is always right, to do what is right.
> - Martin Luther King, Jr.
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