[BioC] sample size estimation in genome wide association studies / packages

[pingzhao Hu]

Hi Alex,
Here are some references:

WJ Gauderman (2002), "Sample size requirements for matched 
case-control studies of gene-environment interaction", Stat Med 21:35-50.
WJ Gauderman (2002), "Sample size requirements for association 
studies of gene-gene interaction", American Journal of Epidemiology, 
155:478-484.
WJ Gauderman (2003), "Candidate gene association studies for a 
quantitative trait, using parent-offspring trios", Genetic 
Epidemiology, 25:327-338.

I think it works for quantitative trait. See the option 'continuous' 
in design.

Pingzhao




At 06:14 AM 1/30/2008, alex lam \(RI\) wrote:
>Hi PingZhao,
>
>Are there any papers describing Quanto? And does it work with
>quantitative traits?
>
>Thanks,
>Alex
>
>--------------------------------------------
>Alex C. Lam
>Roslin Institute (Edinburgh)
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>-----Original Message-----
>From: bioconductor-bounces at stat.math.ethz.ch
>[mailto:bioconductor-bounces at stat.math.ethz.ch] On Behalf Of pingzhao Hu
>Sent: 29 January 2008 18:58
>To: bioconductor at stat.math.ethz.ch
>Subject: [BioC] sample size estimation in genome wide association
>studies / packages
>
>
>    Hi Philippe,
>    try Quanto software
>    [1]http://hydra.usc.edu/GxE/
>    pingzhao
>    ========================================
>    Pingzhao Hu
>    Statistical Analysis Facility
>    The Centre for Applied Genomics (TCAG)
>    The Hospital for Sick Children Research Institute
>    MaRS Centre - East Tower
>    101 College Street, Room 15-705
>    Toronto, Ontario, M5G 1L7, Canada
>    Tel.: (416) 813-7654 x6016
>    Email: phu at sickkids.ca
>    Web: [2]http://www.tcag.ca/statisticalAnalysis.html
>
>
>References
>
>    1. http://hydra.usc.edu/GxE/
>    2. http://www.tcag.ca/statisticalAnalysis.html
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========================================
Pingzhao Hu
Statistical Analysis Facility
The Centre for Applied Genomics (TCAG)
The Hospital for Sick Children Research Institute
MaRS Centre - East Tower
101 College Street, Room 15-705
Toronto, Ontario, M5G 1L7, Canada
Tel.: (416) 813-7654 x6016
Email: phu at sickkids.ca
Web: http://www.tcag.ca/statisticalAnalysis.html