[BioC] nested design with random factor and limma???

Bettina Kulle Andreassen b.k.andreassen at medisin.uio.no
Mon Jul 14 11:25:00 CEST 2008


i have the following dataset:
- 26 indivuals with expressiondata (log-ratio from common ref design)
(random factor: patient)
- each individual has expression data from 1 to 3 different (but fixed)
locations (fixed factor: location)
- 14 controls, 12 patients (fixed factor: group)

i am mainly interested in the group effect!

i tried limma, but it did not seem to work with my random
factor patient?.

any suggestions?
thanks for help!



Bettina Kulle Andreassen
Associate Professor

University of Oslo
Faculty Division Ahus
Institute for clinical epidemiology 
and molecular biology (Epi-Gen)

Sykehusveien 27
N-1474 Nordbyhagen

tel: +47 67927762
fax: +47 67927803

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