[BioC] Test on correlations among a group of genes

[Naomi Altman]

Although I think the concept is clear in some special cases, such as 
all the cross-correlations among genes in 1 set being
higher than all the cross-correlations in another, I am not sure you 
are asking a well defined question.

e.g.  Set 1:      1  .6  .6             Set 
2:    1.  .7  .5
                       .6  1  .6                          .5   1   .7
                       .6 .6   1                          .7  .5   1

Which set is more highly correlated?

--Naomi



At 05:58 PM 2/26/2009, you wrote:




>Dear list,
>
>I have an expression microarray dataset. I would like to compute
>whether the correlations among a group of genes are significantly higher
>compared to all genes. What is the proper statistical test to use? 
>Note that the
>correlation coefficients (a matrix) for the target gene group or the 
>background
>whole set are not all independent, which makes the test a little 
>trickier. I would
>appreciate any thoughts/suggestions.
>
>
>
>Heyi
>
>
>
>
>
>
>
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>
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Naomi S. Altman                                814-865-3791 (voice)
Associate Professor
Dept. of Statistics                              814-863-7114 (fax)
Penn State University                         814-865-1348 (Statistics)
University Park, PA 16802-2111