[BioC] help with normalization

[Richard Friedman]

Dear Caspyr,

	All as one group.

Best wishes,
Rich

On Sep 20, 2010, at 3:50 PM, Casper Shyr wrote:

>
> Hello BioC,
>
>   I have a quick question about the proper way to normalize arrays  
> using gcrma. Right now I have a time series array, basically 10  
> groups in total, each group has 2 replicates. The groups refer to  
> time 0 (control), time 1,2,4,6,10,12...etc.
>
>   When I normalize these cel files, should I normalize them together  
> as one group, or should I perform separate normalizations on each of  
> the groups (i.e. perform 10 separate normalizations on each of the  
> 10 groups)?
>
>
>
> Thank you!
>
> Sincerely,
>
> Casper
> 		 	   		
> 	[[alternative HTML version deleted]]
>
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