[BioC] Normalization questions

Wolfgang Huber whuber at embl.de
Tue Sep 28 22:20:23 CEST 2010

Il Sep/23/10 6:44 PM, ANJAN PURKAYASTHA ha scritto:
>> From reading the literature it seems that calculating the concordance
> correlation coefficient between two normalized arrays is a good measure of
> success of the normalization procedure. Is there a Bioconductor package that
> calculates this?
> Secondly, is there a bioconductor function that identifies outlier spot
> intensities among replicate arrays?
> Appreciate your response.
> Anjan

Dear Anjan

I'd be interested to hear what literature that is.
If your statement were correct, then all normalisation methods should 
just be replaced by ACE (as has indeed been proposed, see Pubmed-ID 
14633397, Faller et al., Normalization of DNA-microarray data by 
nonlinear correlation maximization.)

	Best wishes

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