[BioC] Using proportions...

Wolfgang Huber whuber at embl.de
Thu Nov 17 15:45:58 CET 2011

On 11/17/11 4:58 AM, Jim Silverton wrote:
> Hello,
> Just wanted to find out why in a RNA-seq  with treatment and control, no
> one does the two sample proportion comparison for two features. The total
> reads are large so it should work asymptotically.

Dear Jim

lots of people do, but generally the answer that you get is not what one 
is looking for, because such an analysis tests against (and too 
frequenly rejects) an uninteresting null hypothesis. Have, for instance, 
a look at http://genomebiology.com/2010/11/10/R106 .

Best wishes

Wolfgang Huber

More information about the Bioconductor mailing list