[BioC] F values from topTable with coef=NULL testing all zero or all equal?

[Michael Muratet]

Greetings

This has probably been answered before, but I can't narrow the search  
down enough to find it in the archives. I am looking at the output  
from and documentation for eBayes and realized that the null  
hypothesis for the F statistic is that all the expression values are  
zero. I want to test the hypothesis that all the expression values are  
equal, i.e., rejection implies differential expression. I see from the  
topTable documentation that calling it with coef=NULL will yield an F  
statistic calculation, and I infer from the docs it will include all  
the conditions. What is the null hypothesis: that all the values are  
equal, or that all the values are zero?

Thanks

Mike



Michael Muratet, Ph.D.
Senior Scientist
HudsonAlpha Institute for Biotechnology
mmuratet at hudsonalpha.org
(256) 327-0473 (p)
(256) 327-0966 (f)

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601 Genome Way
Huntsville, Alabama 35806