[BioC] DESeq variance stabilization
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Sun Aug 26 14:18:06 CEST 2012
On Sun, Aug 26, 2012 at 7:24 AM, Lana Schaffer <schaffer at scripps.edu> wrote:
> I have 2 RNAseq datasets which are the same experiment both having 8 control and 8 treated
> Samples. I found that they have slightly different standard deviation values and that the
> Results are different between the 2 datasets. The set with the lower standard deviation
> Gives a longer list of high adj.pvalues. Can you give me any help here?
You could try to include the batch as a covariate in your design and
run all 16 controls vs 16 treated samples in one go.
Is that the type of help you are looking for, or?
Graduate Student: Computational Systems Biology
| Memorial Sloan-Kettering Cancer Center
| Weill Medical College of Cornell University
Contact Info: http://cbio.mskcc.org/~lianos/contact
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