[BioC] Obtaining protein sequence data?

[David Westergaard]

Hi Caitlin,

If you have found the protein sequences at NCBI Protein, they are
(unless otherwise specified) what you could call 'healthy'. I am not
quire sure what you mean by damaged copies. You will have to
investigate the litterature to see which BRCA1/2 mutations are found
in breast cancer. To my knowledge, there are several mutations in the
BRCA genes which have been associated with a higher onset of
especially breast cancer. You can use both UniProt and OMIM to
investigate this.

Best,
David

2012/12/3 Caitlin <bioprogrammer at gmail.com>:
> Hi all.
>
> This is slightly off-topic but I was wondering if anyone here knows where I
> might obtain a complete DNA or protein sequence for both BRCA1 and BRCA2? I
> retrieved protein sequence data from NCBI but I need to obtain two copies
> of each gene, i.e., one normal and another damaged for comparison purposes.
> I am unsure as to whether the protein sequences I have obtained are
> "healthy" copies.
>
> Thanks,
>
> ~Caitlin
>
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>
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