[BioC] Help interpreting many contrasts in one contrast versus many individual contrast matrices

Wang Peter wng.peter at gmail.com
Mon Nov 26 03:38:20 CET 2012


i suggest you should have control for each time point
>> Control: No treatment and time zero (total 6 replicates)
>> Treatment A: time1, time2, time3 and time4 (3 replicates each, total 12)
>> Treatment AB: time1, time2, time3 and time4 (3 replicates each, total 12)
>> Treatment AC: time1, time2, time3 and time4 (3 replicates each,  total 12)
>> Treatment ABC: time1, time2, time3 and time4 (3 replicates each, total 12)

and then do paire-wised comparision


Treatment A vs control : time1 vs , time2, time3 and time4
you can also use the time zero for all the time 1 to 4 to save
money,but not very good

then you do
Treatment AB vs control : time1 vs , time2, time3 and time4

just consider one factor for each comparision, donot consider more than 1

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