[BioC] normalization method & dispersion estimation RNA-seq data

[Ryan C. Thompson]

It doesn't seem that the Wald test is compensating for anything, since 
the authors show that putting their dispersion estimates into edgeR 
causes it to produce nearly identical results.


On 11/26/2012 10:24 AM, Tim Triche, Jr. wrote:
> The supplement mentioned by the authors in their final paragraph is also
> attached (here).  It is worth at least a glance.  I wonder whether the
> notoriously anticonservative Wald test is responsible for recovering
> information lost to over-shrinkage.