[BioC] Why the resuts are so different between the classic and the glm methods?

Jiantao Yu joelyu.2003 at gmail.com
Thu Dec 12 22:54:05 CET 2013


Dear Sir/Madam,

When I used edgeR to do RNA-Seq analysis, I found the datasets of the
resulting DEGs generated by 'Classic' and 'GLM' methods are very different,
the former contain ~460 DEGs, whereas the latter generate ~27,000 DEGs. I
don't know why this was happening. I attached the scripts and the source
data I used, hope you would help me to explain this.

Joel
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"mu1.bam" "mu2.bam" "mu3.bam" "wt1.bam" "wt2.bam" "wt3.bam"
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"AT4G39745&q