[BioC] matchPWM() questions

[Ugo Borello]

Dear all,
I have this transcription factor PWM:
> TFpwm
     [,1] [,2] [,3] [,4] [,5] [,6] [,7] [,8] [,9] [,10] [,11] [,12]
A   52   54   25  133  7   25    5    2    0       90    13    31
C   27  113 167  33 167  37 167 167 167   77   167    52
G   78    0    0    1    1     167  6    3    4       6     21     1
T   10    4   13    2    5    39    2    0   15      3     39    82

As you can see the columns sum to different values:
[1] 167 171 205 169 180 268 180 172 186 176 240 166


May I still use this PWM as argument for the Biostring function matchPWM()?

May I use matchPWM() with more than one PWMs? Could you suggest me how?

Thank you for your help

Ugo