[BioC] Limma vs GEE

Gordon K Smyth smyth at wehi.EDU.AU
Wed Oct 2 15:13:40 CEST 2013

Dear Michael,

It would help if you explained what you mean by "GEE" and why you think it 
might be relevant for your problem.

Best wishes

> Date: Tue, 1 Oct 2013 15:28:36 +0100
> From: Michael Breen <breenbioinformatics at gmail.com>
> To: "bioconductor at r-project.org" <bioconductor at r-project.org>,
> 	"Bioconductor	Mailing List" <bioconductor at stat.math.ethz.ch>
> Subject: [BioC] Limma vs GEE
> Hi all,
> Consider 20 samples at baseline later exposed to treatment. 10 develop a 
> disease and 10 do not develop a disease. Here we want to make a 
> longitudinal assessment of gene expression in the diseased vs 
> disease-free. All done on Affy microarrays.
> Are there any obvious reasons why one would consider limma over GEE for 
> testing for conditional or disease related outcomes?
> Cheers,
> Michael

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