[BioC] Why nbinomGLMTest in DESeq reports zero p values

Yanzhu [guest] guest at bioconductor.org
Fri Feb 7 17:51:08 CET 2014


I used nbinomGLMTest to compare the reduced model and full model given as below, and I got some zero for p values. Is this possible for nbinomGLMTest? If so, what's the potential reason? Thanks 


Full model:
full<-fitNbinomGLMs(cdsFull,count~Line+Rep+Sex)

Reduced model:
reduced<-fitNbinomGLMs(cdsFull,count~Line+Rep)


 -- output of sessionInfo(): 

sessionInfo()
R version 3.0.1 (2013-05-16)
Platform: x86_64-w64-mingw32/x64 (64-bit)

locale:
[1] LC_COLLATE=English_United States.1252  LC_CTYPE=English_United States.1252    LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                           LC_TIME=English_United States.1252

attached base packages:
[1] parallel  stats     graphics  grDevices utils     datasets  methods   base

other attached packages:
[1] DESeq_1.12.1       lattice_0.20-15    locfit_1.5-9.1     Biobase_2.20.1     BiocGenerics_0.6.0 edgeR_3.2.4        limma_3.16.8

loaded via a namespace (and not attached):
[1] annotate_1.38.0      AnnotationDbi_1.22.6 DBI_0.2-7            genefilter_1.42.0    geneplotter_1.38.0   grid_3.0.1
[7] IRanges_1.18.4       RColorBrewer_1.0-5   RSQLite_0.11.4       splines_3.0.1        stats4_3.0.1         survival_2.37-4
[13] XML_3.98-1.1         xtable_1.7-1






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