[BioC] active subnetwork determination

[Paul Shannon]

Hi Benjamin,

The BioNet package

  http://www.bioconductor.org/packages/release/bioc/html/BioNet.html

is somewhat related to Ideker's approach.  It uses expression data and reference networks (protein-protein interactions, primarily) to locate functional modules.  There are a few other candidates for this style of analysis which can be found under the BiocViews topic "Network Enrichment":

   http://www.bioconductor.org/packages/release/BiocViews.html#___NetworkEnrichment

Let us know if we can be of further help.

 - Paul


On Feb 10, 2014, at 9:16 AM, Sidders, Benjamin wrote:

> Hi All,
> 
> Does anyone know if there is a bc package that implements the active
> subnetwork scoring algorithm (or a derivative thereof) as described in:
> 
> Discovering regulatory and signalling circuits in molecular interaction
> networks.
> Ideker, Ozier, Schwikowski & Siegel. Bioinformatics. 2002.
> http://bioinformatics.oxfordjournals.org/content/18/suppl_1/S233.abstract
> 
> Thanks.
> 
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