[R] FDR analyses: minimum number of features

Spencer Graves spencer.graves at pdf.com
Wed Sep 21 16:27:06 CEST 2005

	  Two thoughts on this:

	  1.  Your FDR (Not Franklin Delano Roosevelt) sounds like another name 
for Type I error rate.  The definition of "reasonably reliable FDRs" 
would seem to relate to the status of the literature on this issue among 
researchers in genotyping.  As more reports of FRDs in genotyping are 
published, I would expect that methodology for estimation and the 
standard for accuracy would similarly evolve.

	  2.  Have you tried the Bioconductor (www.bioconductor.org/) 
listserve?  They might be able to say something more useful than a 
general list like this.

	  spencer graves

Dupont, William wrote:

> Dear List,
> We are planning a genotyping study to be analyzed using false discovery
> rates (FDRs) (See Storey and Tibshirani PNAS 2003; 100:9440-5).  I am
> interested in learning if there is any consensus as to how many
> features (ie. how many P values) need to be studied before reasonably
> reliable FDRs can be derived.  Does anyone know of a citation where
> this is discussed?
> Bill Dupont 
> William D. Dupont          phone: 615-343-4100          URL
> http://biostat.mc.vanderbilt.edu/twiki/bin/view/Main/WilliamDupont
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Spencer Graves, PhD
Senior Development Engineer
PDF Solutions, Inc.
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