[R] Dose Profile

[Eik Vettorazzi]

you 'll may be interested in the drc package (a quick start would be 
http://www.bioassay.dk), where you get some nice plots and can fit 
appropriate models as well - very handy if you want to estimate 
effective doses.

hth.


Laura Bonnett schrieb:
> Hi Everyone,
>
> I have data in a long format e.g. there is one row per patient but each
> follow-up appointment is included in the row.  So, a snippet of the data
> looks like this:
>       TrialNo Drug Sex Rand Adate1 Date1 Dose1 Time1 Adate2 Date2 Dose2
> Time2  B1001029 LTG M 15719 30/04/2003 15825 150 106 29/08/2003 15946 200
> 227  B1117003 LTG M 15734 30/04/2003 15825 200 91 03/09/2003 15951 250 217
> B138015 LTG M 14923 06/02/2001 15012 225 89 08/05/2001 15103 300 180
> B112003 TPM F 14914 15/01/2001 14990 60 76 05/03/2001 15039 100 125
> Of course, not everyone has the same number of follow-up appointments and so
> there may be some column entries that are NAs.
>
> What I'd like to do is a dose profile i.e. a plot of time on the x-axis
> agaisnt dose on the y-axis for each patient ideally colouring lines
> according to drug.  Does anyone know how I can do this?  Someone at work has
> suggested that I use plot and then loess.smooth but I don't really know what
> to do.
>
> Thank you very much for your help,
>
> Laura
>
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>
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-- 
Eik Vettorazzi
Institut für Medizinische Biometrie und Epidemiologie
Universitätsklinikum Hamburg-Eppendorf

Martinistr. 52
20246 Hamburg

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