[R] PKPD modelling in R

Kozielska-Reid MA, Magdalena m.a.kozielska-reid at pl.hanze.nl
Mon Oct 15 12:21:41 CEST 2012

Dear Marc,

Thank you for your reply.

>From the link you send only nlmeODE seems to be useful for my purposes (PKPD modelling with user defined differential equations).
But I indeed asked the author of the package and he said that he is planning to update it soon so that it uses deSolve.

From: Marc Schwartz [marc_schwartz at me.com]
Sent: 08 October 2012 18:01
To: Kozielska-Reid MA, Magdalena
Cc: r-help at r-project.org
Subject: Re: [R] PKPD modelling in R

On Oct 8, 2012, at 10:04 AM, "Kozielska-Reid MA, Magdalena" <m.a.kozielska-reid at pl.hanze.nl> wrote:

> Dear all,
> I have two questions:
> 1. Does anyone know if nlmeODE package will work once odesolve is discontinued? If i understand well nlmeODE depends on odesolve.
> 2. Can anyone suggest another package I could use to fit complex PKPD models (described using differential equations) to data?
> Thanks a lot!
> Magdalena

You should probably contact the author of nlmeODE to see if he plans to update his package to perhaps use deSolve instead as well as other CRAN required updates (eg. a NAMESPACE). nlmeODE has not been updated in well over two years, which would logically raise some suspicions. Presumably nlmeODE will begin to more materially fail CRAN checks once odesolve is formally deprecated and may itself be deprecated/orphaned as a result. It already has NOTE entries in the CRAN checks for problems already found.

If you have not, you might want to look at the CRAN task view here:


which might provide some possible alternatives.


Marc Schwartz

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