[R] p-values from multiple testing

Bert Gunter gunter.berton at gene.com
Tue Jul 23 16:58:23 CEST 2013

Your question has effectively nothing to do with R, so is off topic
here. Post on a statistics or bioinformatics site like
stats.stackexchange.com .

I'll just mention that this is a ubiquitous issue  in, e.g. gene
testing (p>>n), is controversial, philosophical, and complex. You may
have a good bit of reading to do.

-- Bert

On Tue, Jul 23, 2013 at 7:50 AM, Jie <jimmycloud at gmail.com> wrote:
> Dear All,
> I performed thousands of testings and obtained p-values.
> And then I did two-sided uniform KS test of the p-values, the result
> claimed it is uniform.
> So does it mean that my model are wrong? Because I expect more small
> p-values near 0.
> This is a preliminary step before correcting the multiplicity.
> Attached is hist of p-values (does this list allow attachment?). The ks test:
> One-sample Kolmogorov-Smirnov test
> D = 0.0493, p-value = 1.388e-06
> alternative hypothesis: two-sided
> Thank you for your attention.
> Best wishes,
> Jie
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Bert Gunter
Genentech Nonclinical Biostatistics

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