[R] Differences in output of lme() when introducing interactions

[John Kane]

I clearly am going to have to improve my stats knowledge by reading McPhearson. To heck with Senn- too complicated. :)

Thanks Terry.

John Kane
Kingston ON Canada


> -----Original Message-----
> From: therneau at mayo.edu
> Sent: Thu, 23 Jul 2015 14:07:00 -0500
> To: r.turner at auckland.ac.nz, therneau at mayo.edu
> Subject: Re: [R] Differences in output of lme() when introducing
> interactions
> 
> The following are in parody (but like all good parody correct wrt the
> salient features).
> The musings of
> Guernsey McPhearson
>     http://www.senns.demon.co.uk/wprose.html#Mixed
>     http://www.senns.demon.co.uk/wprose.html#FDA
> 
> 
> In formal publication:
>   Senn, Statistical Issues in Drug Development, second edition, Chapter
> 14: Multicentre Trials
>   Senn, The many modes of meta, Drug information journal, 34:535-549,
> 2000.
> 
> The second points out that in a meta analysis no one would ever consider
> giving both large
> and small trials equal weights, and relates that to several other bits of
> standard
> practice.  The 'equal weights' notion embedded in a fixed effects model +
> SAS type 3 is an
> isolated backwater.
> 
> Terry T.
> 
> PS. The "Devils' Drug Development Dictionary" at the same source has some
> gems. Three
> rather random choices:
> 
> Bayesian - One who, vaguely expecting a horse and catching a glimpse of a
> donkey, strongly
> concludes he has seen a mule.
> 
> Medical Statistician - One who won't accept that Columbus discovered
> America because he
> said he was looking for India in the trial Plan.
> 
> Trend Towards Significance - An ever present help in times of trouble.
> 
> 
> 
> On 07/22/2015 06:02 PM, Rolf Turner wrote:
>> On 23/07/15 01:15, Therneau, Terry M., Ph.D. wrote:
>> 
>> <SNIP>
>> 
>>> 3. Should you ever use it [i.e. Type III SS]?  No.  There is a very
>>> strong inverse
>>> correlation between "understand what it really is" and "recommend its
>>> use".   Stephen Senn has written very intellgently on the issues.
>> 
>> Terry --- can you please supply an explicit citation?  Ta.
>> 
>> cheers,
>> 
>> Rolf
>> 
> 
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