[BioC] ttest or fold change

[Jason Hipp]

I am comparinga relatively homogeneous cell culture to another that has been treated, and am using RMA.  
 
I only have 3 replicates of each.  Would you recommend a 2 tailed equal variance t test?  
I also thought I read that with such few replicates, a fold change would be better than a t test?
If I get a t test of .0001, and a fold change of 1.2, is this a reliable change using RMA?
 
Thanks,
Jason