[BioC] Multtest Question!

Puhong Gao gaopuho@pi.cpmc.columbia.edu
Tue, 11 Feb 2003 12:18:15 -0500

Hi, all,

In the documentation of the Multtest R package, the raw p values were generated based on the standard Gaussian distribution. Can someone explain to me why it should be like that? What situations can it be applicable to? The p values based on the standard Gaussian distribution are much smaller than those based on the t-distributions. The consequence of this is more genes will be picked up as significant. How can this be explained? Your inputs will be very appreciated.

Have a great day,

Puhong Gao, PhD
Dept. of Developmental Psychobiology
NYSPI/Columbia University
1051 Riverside Drive
New York, NY 10032
(212) 543-5710

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