[BioC] rma and MM

Ben Bolstad bolstad at stat.berkeley.edu
Wed Jun 25 03:31:43 MEST 2003


The current implementations of RMA do not use MM in any way (as you
might calculate using rma() or expresso() or justRMA()). Some of the
earlier versions used MM in the computation of the background, but this
is no longer the case.

Thanks,

Ben

> We are having a little debate about whether RMA is using MM oligos at all.
> I know that PM.only is the method that calls the gene expression index, but
> Are MM intensities used in the calculation for the background correction?  I
> thought I'd put this out to get the definitive answer.
> 

-- 
Ben Bolstad <bolstad at stat.berkeley.edu>
http://www.stat.berkeley.edu/~bolstad



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